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ICHORtec IP portfolio

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Patents

Patent 1

METHOD AND OPTODE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE LIQUID

Abstract

Discloses calibration free chemical sensor (electrolytes, proteins etc.)

Application numbers

  • DE: DE102019132525B3 (granted)
  • USA: US11698376B2 (granted)
  • EU: EP4065964B1
  • WO: WO2021209565A3 

Patent 2

IN-VITRO METHOD AND DEVICE FOR DETECTING A TARGET NUCLEIC ACID

Abstract

Discloses the method to detect nucleic acid in analytes, general principle of the technology

Application numbers

  • USA: US20210324455A1
  • EU: EP3896430A1
  • WO: WO2021209565A2

Patent 3

SENSOR VESSEL FOR THE OPTICAL DETECTION OF BIOMARKERS

Abstract

Describes a sensor vessel where an optical fiber comes into contact with an analyte

Application numbers

  • USA: U.S. Patent Application No. 18/721,127 (Recordation date 30/08/2024)
  • EU: EP4187230A1
  • WO: WO2023094647A1

Patent 4

A METHOD TO CHARACTERIZE NUCLEIC ACID

Abstract

Discloses a method to analyze nucleic acids:

  • on presence and/or appearance of polymorph nucleotides
  • on presence of proteins and polyamines, etc.

Application numbers

  • USA: U.S. Patent Application No. 18/889,250, with prioritized examination (Recordation date  8/09/2024)
  • EU: EP24191540.4 (Recordation date 15/08/2024)
  • WO: –

PUBLICATIONS

PUBLICATION

A METHOD TO MEASURE MOLECULAR HYBRIDIZATION

Abstract

Here we describe a new method for the quantitation of MB hybridization based on the measurement of changes in free energy instead of the fluorescence intensity. The MB energy state can be measured by micro-fluorescence detection. The approach allowed to determine hybridization energy of the MB with target nucleotide directly from fluorescence spectra and distinguish the MB in unfolded and hybridized states. Moreover, the method enabled us to discriminate between DNA duplexes with perfect complementarity or a single-nucleotide mismatch, based on the first direct experimental prove of enthalpy-entropy compensation.

PLOS ONE

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